Assessment of Microelastic Properties of Bone Using Scanning Acoustic Microscopy: A Face-to-Face Comparison with Nanoindentation

概要

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The current work aimed at comparing, on site-matched cortical bone tissue, the micron-level elastic modulus $E_{\text{a}}$ derived from 200 MHz-scanning acoustic microscopy (SAM) acoustic impedance ($Z$) combined with bone mineral density (assessed by synchrotron radiation microcomputed tomography, SR-μCT) to nanoindentation modulus $E_{\text{n}}$. A good correlation was observed between $E_{\text{n}}$ and $Z$ ($R^{2}=0.67$, $ p<0.0001$, root mean square error $\mathrm{RMSE}=1.9$ GPa). The acoustical elastic modulus $E_{\text{a}}$ derived from $Z$ showed higher values of $E$ compared to nanoindentation moduli. We assumed that the discrepancy between $E_{\text{a}}$ and $E_{\text{n}}$ values may likely be due to the fixed assumed value of Poisson’s ratio while values comprised between 0.15 and 0.45 have been reported in the literature. Despite these differences, a highly significant correlation between $E_{\text{a}}$ and $E_{\text{n}}$ was found ($R^{2}=0.66$, $ p<0.001$, $\mathrm{RMSE}=1.8$ GPa) suggesting that SAM can reliably be used as a modality to quantitatively map the local variations of tissue-level bone elasticity.
2009-07-25