Cell Palpation System Based on a Force Measurement by Optical Tweezers for Investigation of Local Mechanical Properties of a Cell Membrane
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概要
- 論文の詳細を見る
We have developed a cell palpation system, which enables to investigate mechanical properties of a cell in local with an optically manipulated particle. In this system, the particle attached on a cell surface is forced to move back-and-forth in sinusoidal manner by optical tweezers. Position of the particle position is recorded and analyzed to extract force exerted on the particle by using a physical model of the particle. We have demonstrated to measure cell membrane stiffness in local and temporal change of that with the detection limit of the force in pN order.
- 2009-12-25
著者
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Sugiura Tadao
Department Of Applied Physics Osaka University
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Miyoshi Hideaki
Department of Bioinformatics and Genomics, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan
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Minato Kotaro
Department of Bioinformatics and Genomics, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan
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