Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction
スポンサーリンク
概要
- 論文の詳細を見る
Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore the molecular mechanism of the hepatoprotective effects of ASD on BRL cells and isolated rat liver mitochondria. We investigated the effects of ASD on rotenone-induced toxicity in BRL cells. The results showed that ASD inhibited the accumulation of reactive oxidant species, ATP deficiency, and mitochondrial membrane potential dissipation; ameliorates mitochondrial respiratory dysfunction, and improved the activity of complex I in a concentration-dependent manner, indicating that ASD likely improved mitochondrial function. ASD suppressed rotenone-induced BRL cell apoptosis and increased Bcl-2/Bax ratio. These results suggest that ASD may exert hepatoprotective effects against rotenone-induced toxicity through mitochondria. This study supports our previous research that ASD possesses hepatoprotective activity in vivo and it is worthy of further study.
- 公益社団法人 日本薬理学会の論文
公益社団法人 日本薬理学会 | 論文
- Neurotoxin A2NTX Blocks Fast Inhibitory and Excitatory Transmitter Release From Presynaptic Terminals
- Loxiglumide, L - 364,718 and L - 365,260 Prevent the Inhibition of Spontaneous Acetylcholine Release from the Frontal Cerecral Cortex of Freely Moving Rat Peripherally Administered with Cholecystokinin - 8S
- A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.
- Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection : Role of Tachykinin Receptors
- Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.