Poiseuilleの法則を用いたin vivo末梢血管抵抗の実験的評価
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To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (R<SUB>t</SUB>) and single arteriolar resistance (R<SUB>a</SUB>) obtained from in vivo animal experiments. R<SUB>t</SUB> and R<SUB>a</SUB> values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The R<SUB>t</SUB> and R<SUB>a</SUB> values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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