DHA concentration of red blood cells is inversely associated with markers of lipid peroxidation in men taking DHA supplement

スポンサーリンク

概要

• 論文の詳細を見る

• An increase in the proportion of fatty acids with higher numbers of double bonds is believed to increase lipid peroxidation, which augments the risk for many chronic diseases. (n-3) Polyunsaturated fatty acids provide various health benefits, but there is a concern that they might increase lipid peroxidation. We examined the effects of docosahexaenoic acid [22:6 (n-3)] supplementation on lipid peroxidation markers in plasma and red blood cells (RBC) and their associations with red blood cell and plasma fatty acids. Hypertriglyceridemic men (n = 17 per group) aged 39–66 years participated in a double-blind, randomized, placebo-controlled, parallel study. They received no supplements for the first 8 days and then received 7.5 g/day docosahexaenoic acid oil (3 g/day docosahexaenoic acid) or olive oil (placebo) for 90 days. Fasting blood samples were collected 0, 45, and 91 days after supplementation. Docosahexaenoic acid supplementation did not change plasma or RBC concentrations of lipid peroxidation markers (total hydroxyoctadecadienoic acid, total hydroxyeicosatetraenoic acid, total 8-isoprostaglandin F2α, 7α-hydroxycholesterol, 7β-hydroxycholesterol) when pre- and post-supplement values were compared. However, the post-supplement docosahexaenoic acid (DHA) concentration was inversely associated with RBC concentrations of ZE-HODE, EE-HODE, t-HODE, and total 8-isoprostaglandin F2α, (p<0.05). RBC concentration of hydroxycholesterol was also inversely associated with DHA but it did not attain significance (p = 0.07). Our results suggest that increased concentration of DHA in RBC lipids reduced lipid peroxidation. This may be another health benefit of DHA in addition to its many other health promoting effects.

著者

• Shigeri Yasushi

  Health Research Institute National Institute Of Advanced Industrial Science And Technology

• Ishida Noriko

  Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)

• Shichiri Mototada

  Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)

• Yoshida Yasukazu

  Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)

• Adkins Yuriko

  Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis

• Umeno Aya

  Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)

• Fedor Dawn

  Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis

• Mackey Bruce

  Western Regional Research Center, ARS, USDA

• Kelley Darshan

  Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis

関連論文

• DPE-030 Serum Concentrations of Linoleic Acids and Their Derivatives by Lipid Peroxidation are Increased in Patients with CD36 Deficiency(DPE05,Lipid Disorders (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circula
• 3TA3-06 酸化ストレスによる細胞サイズリポソームの動的構造変化(生体膜・人工膜-構造・物性,第47回日本生物物理学会年会)
• Assessment of the Antioxidant Capacity of Natural Fruit Extracts by Inhibition of Probe Decay and Plasma Lipid Peroxidation
• Evaluation of Acute Oxidative Stress Induced by NiO Nanoparticles In Vivo and In Vitro
• Decomposition of Intact Chicken Feathers by a Thermophile in Combination with an Acidulocomposting Garbage-Treatment Process
• Taxonomic characterization and metabolic analysis of the Halomonas sp. KM-1, a highly bioplastic poly(3-hydroxybutyrate)-producing bacterium(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Desorption/Ionization Efficiency of Peptides Containing Disulfide Bonds in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
• DHA concentration of red blood cells is inversely associated with markers of lipid peroxidation in men taking DHA supplement

スポンサーリンク