家兎副鼻腔自然孔の機能形態学的研究-三次元的微小血管構築の観察と病態組織化学的検索を中心に-

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To elucidate the pathogenesis of sinusitis, the microvasculature and surface- ultrastructure of ostium in rabbits were examined by scanning electron microscopy, in addition to histochemical investigation of the mucosa.<BR>The scanning electron microscopic obse r vation by the injection replica method revealed that the microvasculature around the ostium was different from that in other parts of the nasal cavity such as the nasal turbinate and septal mucosa. Capillaries around the ostium had a relatively flat and reticular structure, whereas those in the turbinate had a three dimensional network composed of many loops.<BR>Histochemical study on ostium mucosa was performed in rabbi t s with experimentally induced sinusitis. The rabbits were divided into three groups; a) a control group, b) a sensitization group with egg albumin, c) a sinusitis group induced by injection of endotoxin of H. Influenzae after egg albumin sensitization.<BR>The number of goblet cells lining the surface of the epi t h elium around the ostium was higher but that of ciliated cells was lower in both the sensitization and the sinusitis groups than in the control group. A characteristic findings was that reaction products were observed in the goblet cells stained with lectins, which bind to specific sugar residues, in all of the groups.<BR>It was concluded that the pathogenesis of the sinusitis was closely related to the pathology of the ostium.
耳鼻咽喉科臨床学会の論文