Hybrid Odontogenic Lesion of the Mandible: A Rare Case Report with Literature Review

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A hybrid lesion is defined as being a "lesion showing the combined histopathological characteristics of two or more previously recognized odontogenic tumors and/or cysts of different categories." Adenomatoid Odontogenic Tumor (AOT) is relatively rare, and was previously described as a histological variant of ameloblastoma, but is now recognized as a separate entity by the World Health Organization, representing 3-7% of all odontogenic tumors. AOT is a slow-growing lesion that is thought to arise from odontogenic epithelium because of its predilection for tooth-bearing bone, with varying degrees of inductive changes in connective tissue. It is sometimes referred to as the "two-three tumor" because about two thirds occur in the maxilla, two thirds occur in young women, two thirds are associated with an unerupted tooth, and two thirds of these teeth are canines. Cases of maxillary involvement are more common, usually in the anterior region of the jaw. The present case describes the concomitant occurrence of AOT, dentigerous cyst and CEOT in the anterior portion of the mandible of a 13-year-old male patient. PAS staining was performed for confirmation of amyloid components, followed by Congo Red staining.
日本大学松戸歯学部口腔科学研究所の論文