Sensitive Quantitation of Residual Phenylhydrazine in Antipyrine by LC-ICP-MS with Iodo Derivatization
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概要
- 論文の詳細を見る
Phenylhydrazine is a genotoxic impurity commonly used as a raw material in active pharmaceutical ingredients. In this study, a novel method, using inductively coupled plasma–mass spectrometry combined with two-dimensional liquid chromatography (LC-ICP-MS), was employed for the quantitation of residual phenylhydrazine in antipyrine. The compound 2,3,5-triiodobenzoyl chloride, which contains three iodine atoms, was investigated as a derivatization reagent. The DL 0.06 ppm was obtained, and the method was applied to the quantitation of residual phenylhydrazine in antipyrine. No residual phenylhydrazine was detected in five lots of antipyrine obtained from the commercial source.
- 社団法人日本分析化学会の論文
著者
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Harigaya Koki
Analytical Chemistry Research Department Cmc Research Laboratory Mitsubishi Tanabe Seiyaku Co. Ltd.
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Nishi Hiroyuki
Department Of Anesthesiology Faculty Of Medicine University Of The Ryukyus
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Haginaka Jun
School of Pharmaceutical Sciences, Mukogawa Women's University
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NISHI Hiroyuki
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yasuda Women's University
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YAMADA Hiroyuki
Analytical Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corp.
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HORIMOTO Shingo
Analytical Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corp.
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