A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate

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概要

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• In the present study, biomolecule-stabilized Au nanoclusters were demonstrated as a novel fluorescence probe for sensitive and selective detection of pazufloxacin mesilate (PZFX) for the first time. The linear decrease in the fluorescence intensity of Au nanoclusters induced by PZFX allowed for the quantitative detection of PZFX in the range of 0.15 μg/mL to 1 mg/mL, and the detection limit for PZFX was 0.2 μg/mL. Circular dichroism spectroscopy and fluorescence decay studies were then performed to discuss the quenching mechanism. In addition, practical application of the present approach was also demonstrated for real samples, which suggested its great potential for accurate analysis of similar drugs.

• 社団法人日本分析化学会の論文

著者

• Wu Yuqing

  State Key Laboratory For Supramolecular Structure And Materials Jilin University

• CAO Xueling

  State Key Laboratory of Supramolecular Structure and Materials, Jilin University

• LI Hongwei

  State Key Laboratory of Supramolecular Structure and Materials, Jilin University

• LIAN Lili

  State Key Laboratory of Supramolecular Structure and Materials, Jilin University

• LOU Dawei

  Department of Chemistry, Jilin Institute of Chemical Technology

関連論文

• Pressure-induced Structural and Hydration Changes of Proteins in Aqueous Solutions
• A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate

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