HJC, a New Arylnaphthalene Lignan Isolated From Justicia procumbens, Causes Apoptosis and Caspase Activation in K562 Leukemia Cells

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概要

• 論文の詳細を見る

• The aim of this study is to investigate whether HJC, isolated from Justicia procumbens for the first time, can suppress the proliferation and induce apoptosis of human leukemia K562 cells and finally clarify its related mechanism. The chemical structure of HJC was validated by LC-ESI-MS/MS, cytotoxicity was assayed using MTT, and apoptosis was investigated by flow cytometry. These assays indicated that HJC remarkably inhibited the growth in K562 cells by decreasing cell proliferation, reducing the SOD activity, enhancing ROS levels and inducing apoptosis. Activation of caspase-3 indicated that HJC may be inducing intrinsic and extrinsic apoptosis pathways and that HJC-induced apoptosis was caspase-dependent. This study suggests that HJC is a high-potency anti-tumor agent, and it induces apoptosis through a caspase-dependent pathway in human leukemia K562 cells. It also presents a potential alternative to leukemia therapy.

• 公益社団法人 日本薬理学会の論文

著者

• Kong Weijun

  Institute Of Chinese Materia Medica 302 Hospital Of People's Liberation Army:pharmacy College L

• Luo Jiaoyang

  Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China

• Yang Meihua

  Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China

関連論文

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• HJC, a New Arylnaphthalene Lignan Isolated From Justicia procumbens, Causes Apoptosis and Caspase Activation in K562 Leukemia Cells

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