Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats

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概要

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• Tacrolimus (Tac) is a core immunosuppressive drug in human organ transplantation. In feline kidney transplantation, however, the cost of Tac therapy is a significant obstacle. Clarithromycin (CLM) increases the blood trough level of Tac, effectively reducing the Tac dosage in human transplant patients. The interaction between CLM and Tac in cats has not been reported. In this study, the effect of multiple CLM dosing on the pharmacokinetics of Tac in three healthy cats was investigated. The treatments included Tac at 0.3 mg/kg and Tac at 0.3 mg/kg + multiple-dose CLM at 10 mg/kg. Co-administration of CLM and Tac resulted in significant increases in the oral bioavailability of Tac. These preliminary findings suggest that administration of multiple doses of CLM may decrease the required Tac dosage in Tac-based immunosuppressive therapy used as an alternative to the classic cyclosporine-based protocol for feline renal transplantation.

• 公益社団法人 日本獣医学会の論文

著者

• Okamura Yasuhiko

  Division Of Endocrine Surgery Department Of Surgery Kawasaki Medical School

• KATAYAMA Masaaki

  Division of Small Animal Surgery, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• SHIMAMURA Shunsuke

  Division of Small Animal Internal Medicine, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• UZUKA Yuji

  Division of Small Animal Surgery, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• SHIMAMURA Shunsuke

  Division of Small Animal Internal Medicine, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• USHIO Taku

  Division of Small Animal Surgery, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

関連論文

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• Effect of Multiple Oral Dosing of Fluconazole on the Pharmacokinetics of Cyclosporine in Healthy Beagles
• Serum Glial Fibrillary Acidic Protein as a Diagnostic Biomarker in Dogs with Progressive Myelomalacia
• Preliminary Study of Effects of Multiple Oral Dosing of Clarithromycin on the Pharmacokinetics of Cyclosporine in Dogs
• Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats

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