Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from Anemone raddeana

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概要

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• First, Raddeanin A, a cytotoxic oleanane-type triterpenoid saponin isolated from Anemone raddeana REGEL, was synthesized. Stepwise glycosylation was adopted in the synthesis from oleanolic acid, employing arabinosyl, glucosyl and rhamnosyl trichloroacetimidate as donors. The chemical structure of Raddeanin A was confirmed by means of 1H-NMR, 13C-NMR, IR, MS and elemental analysis, which elucidated the structure to be 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside oleanolic acid. Biological activity tests showed that in the range of low concentrations, Raddeanin A displayed moderate inhibitory activity against histone deacetylases (HDACs), indicating that the HDACs' inhibitory activity of Raddeanin A may contribute to its cytotoxicity.

• 公益社団法人 日本薬学会の論文

著者

• Wang Zhou

  Bioengineering College, Xihua University

• Wu Yong

  West China School of Pharmacy, Sichuan University

• Qian Shan

  Bioengineering College, Xihua University

• Chen Quan

  Bioengineering College, Xihua University

• Guan Jin

  Bioengineering College, Xihua University

関連論文

• Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from Anemone raddeana

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