Biliary carcinoma associated with pancreaticobiliary maljunction
スポンサーリンク
概要
- 論文の詳細を見る
In 1994, we first reported an experimental model for the efficient induction of extrahepatic biliary carcinoma in hamsters, which consists ot cholecystoduodenostomy with dissection of the extrahepatic bile duct at the distal end of the common duct (CD) and following administration of Nnitrosobis (2-oxoproyl) amine (BOP). The 74 hamsters that tolerated the CD procedure were treated weekly by BOP injection for 9 weeks and then killed on the 12 th,16 th and 20 th week after the initiation of BOP treatment. Extrahepatic bile duct carcinoma developed in 16%,24% and 41%and gallbladder carcinoma occurred in 58%,81% and 82% of the hamsters, respectively, at the corresponding times of killing.<BR>Cholecystoileostromy (CI) was employed instead of CD in hamsters to reveal the role of duodenal juice regurgitation into the biliary system. The incidences of extrahepatic carcinoma and gallbladder carcinoma were significantly higher in CD group than that in CI group. The pathophysiological entity in our CD model was considered to be caused by the mixing of pancreatic juice, bile and duodenal juice. To test spontaneous development of biliary carcinoma in the CD model,14 hamsters that underwent the CD procedure were followed for one year. An extrahepatic bile duct carcinoma developed in one of the animals.
- Japan Biliary Associationの論文
Japan Biliary Association | 論文
- Relationships between congenital biliary dilatation and ventral pancreatic duct in patient with branch fusion type of ventral and dorsal pancreatic ducts
- Report of a case with primary intrahepatic bile duct stones of calcium carbonate
- A stoichiometrical and ultrastructural study on cell membrane damage by bile salt using human red blood cells
- Biliary carcinoma associated with pancreaticobiliary maljunction
- Characteristics of pigment gallstones: correlation between their clinical classification and results of infrared