The Effects of Saponin on Sinusoids and Capillaries in Various Organs: An Electron Microscopic Study
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A comparative electron microscopic study was made on the effects of saponin on the sinusoids and capillaries of various organs of rabbits and the sinusoids of the bone marrow in cats, dogs, rats and mice. Animals received an intravenous injection of saponin at a dose of 2 mg per kg of body weight and were sacrificed 6 hours after injection.<BR>In rabbits, the sinusoidal endothelium of the bone marrow showed extensive damage, whereas the endothelial cells lining the liver sinusoids, those lining discontinuous capillaries in the small intestine and adrenal cortex, and those lining continuous capillaries in the muscles (diaphragm and biceps brachii muscle) remained unaffected. Among the various animals exathined, only in the case of cats did saponin induce results similar to the marrow sinusoid damage found in rabbits.
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