Supplementary Studies of the Saponin-Induced Colonization of the Bone Marrow Elements in Rabbits:II. The Influence of Unilateral Ligation of the Renal Blood Vessels on the Colonization Pattern of Bone Marrow Elements in the Kidney

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1. A series of rabbits was subjected to ligation of the left renal artery and vein. After ligation, there occurred massive necrosis of the kidney parenchyma through hyaline degeneration, but in most instances some portions of cortical parenchyma remained relatively intact.<BR>2. The subsequent, intravenous injection of a large dose of saponin produced accumulation of immature blood cells in the dilated lumen of small blood vessels 'within or around the areas remaining relatively intact, to a slight extent at 24 and 48 hours and to a great extent at 72 hours. This tendency was most striking in the 1-week group in which saponin was injected 7 days after ligation of the renal blood vessels.<BR>3. In the perip h eral blood there was a remarkable erythroblastosis at 24 and 48 hours and to a somewhat lesser degree at 72hours after saponin injection.<BR>4. In the left kidney of control animal without saponin injection, no accumulation of immature blood cells was observed anywhere, although small islands of normal appearing glomeruli also occurred.<BR>5. These findings lead to the conclusion that aseptic inflammation caused by massive necrosis of the kidney parenchyma considerably enhances intravascular accumulation of immature blood cell liberated from the bone marrow in the inflammed areas.
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