Isolation and characterization of a Lactobacillus acidophilus strain L92 that can survive in human gastrointestinal tract

概要

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Twenty-two strains of Lactobacillus acidophilus were tested for their bile acid tolerance. The recovery rates of three of these strains were measured in feces of volunteers administered individual doses of these strains. A L92 strain with the highest bile acid tolerance (5.77%)showed the highest recovery rate in feces (93%). On the other hand, a CP1553 strain with the lowest bile acid tolerance (0.75%) showed the lowest recovery rate in feces (0.0056%). Positive correlation was observed between the bile acid tolerance and the recovery of the tested Lactobacillus acidophilus strains in feces. Bile acid tolerance seemed to be very important characteristic for the survival and reisolation of strains from feces for Lactobacillus acidophilus. Moreover, the selected L92 strain was able to prevent attachment of harmful bacteria to Caco-2cells. These results indicate the potential usefulness of Lactobacillus acidophilus strain L92 as a probiotic.
Japan Society for Lactic Acid Bacteriaの論文