A Case of Depression Followed by Parkinsonism

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A 58-year-old housewife, who had been suffering from depressive mood, psychomotor inhibition and sleep disturbance since April,1988, was admitted to our clinic in Juiy, when she attempted suicide. First, she was given antidepressant drugs, which produced several side effects and aggravated she depressive symptoms. At the same time, extrapyramidal disturbances such as muscular rigidity and festinating gait associated with bradyphrenia appeared and comiplicated. Then, as the antidepressant medcation was discontinued and replaced with levodopa product, the symptoms mentioned above have gradually been subsided and disappeared.<BR>It is well known that depressive mood is usually observed in case of parkinsonism inculuding drug induced extrapyramidalism and their causality and correlation are not yet clear. It is, however, considered that there is a certain reactive factor to the physical disorders and also shat there is a common biochemical basis consisting of metabolic dysfunctions of intracerebral monoamines behind the depression and parkinsonism. In the present case, the existence of the biochemical background common to the mental and nervous disorders has to the considered, particularly because the depression appeared to preceded she appearance of extraoyramidal disturbances. By the way, antidepressants were not so effective to the depressive symptoms as expected, while levodopa has improved not only extrapyramidal disturbances but also various psychiatric disorders. It is quite possible that the extrapyramidal disturbances were induced and aggravated under the antidepressant medications in the present case.
The Medical Society of Kansai Medical Universityの論文

A Case of Depression Followed by Parkinsonism

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The Medical Society of Kansai Medical University | 論文

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