Effects of YM-14673 on the Central Nervous System:An Electrophysiological Study of Arousal Reaction and Evoked Muscular Discharges
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The effects of YM-14673 on central nervous system activity in rabbits were investigated electrophysiologically.<BR>1. The threshold of arousal reaction of the cerebral cortex and hippocampus and those of evoked muscular discharges in the fore and hind limbs due to stimulation of the brain stem reticular formation decreased after administration of YM-14673.<BR>2. The threshold of the evoked muscular discha rges in the fore and hind limbs due to stimulation of the cerebral cortex decreased after administration of YM-14673.<BR>3. The threshold of the evoked muscular discharges in the fore and hi nd limbs due to stimulation of the hippocampus increased after administration of YM-14673.<BR>4. The threshold of arousal reaction and evoked muscular dis charges in the fore and hind limbs due to stimulation of the cerebral cortex, which had been elevated by destruction of the internal capsule, was lowered after daily administration of YM-14673 0.05mg/kg.<BR>The findings suggest that YM-14673 has a consciousness-arousing effect, a facil itatory effect on the pyramidal system and an inhibitory effect on the extrapyramidal system.
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