Pharmacological Studies of Xanthine Derivatives (II):In Special Reference to Diuretic Action of 7-(γ-Ethoxy-β-hydroxypropyl)-theophylline and 7-(γ-Allyloxy-β-hydroxy-propyl)-theophylline

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Thirty-seven xanthine derivatives were examined in their diuretic action on the male rabbit using a modified Burn's method. When administered intravenously, some xanthine derivatives were found to have noticable diuretic action; especially after 7-(γ-ethoxy-βhydroxy-propyl)-theophylline (X 49) administration, remarkable diuresis was produced in rabbit. The potency of X (49) in diuretic action may be about the same one as of aminophylline.<BR>By oral dministration 7-(γ-allyloxy-β-hydroxy-propyl)-theophylline (X65)was the most active one in the examined compounds. The adequate dose of (X 49) and X (65) enough to produce the significant diuresis was 50mg i. v. and 100mg orally per kg of body weight, respectivelly.<BR>The LD50 values of X (49) and X (65) given intraperitoneally were 11.5mg and 10.4mg per 10g of body weight of white mice respectivelly.
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