Subcellular localization of KL-6 mucin in intraductal papillary mucinous neoplasm of the pancreas
スポンサーリンク
概要
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This study aimed to clarify the expression profile of KL-6 mucin in intraductal papillary mucinous neoplasm (IPMN) and its relation to tumor malignancy. Expression of KL-6 mucin in 38 IPMNs (intraductal papillary mucinous adenoma (IPMA), 24 cases; minimally invasive intraductal papillary mucinous carcinoma (MI-IPMC), 8 cases; invasive carcinoma originating from IPMC (IC-IPMC), 6 cases) and 66 pancreatic ductal adenocarcinomas (PDACs) was evaluated immunohistochemically. IC-IPMCs and MI-IPMCs had positive staining of KL-6 mucin whereas 58% of IPMAs tested negative. Subcellular localization of KL-6 mucin varied among IPMNs whereas all of the PDAC had positive expression in the circumferential membrane and cytoplasm of cancer cells. IC-IPMCs and MI-IPMCs had a higher frequency of circumferential membrane and cytoplasmic localization of KL-6 mucin than did IPMAs. These results suggest that localization of KL-6 mucin could be used to predict the malignancy of IPMN.
著者
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Seyama Yasuji
Hepato-biliary-pancreatic Surgery Division Department Of Surgery Graduate School Of Medicine Univers
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Inagaki Yoshinori
Hepato-biliary-pancreatic Surgery Division Department Of Surgery Graduate School Of Medicine The Uni
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Tang Wei
Hepato-biliary-pancreatic Surgery Division Department Of Surgery Graduate School Of Medicine The Uni
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Kokudo Norihiro
HepatcrBiliary-Pancreatic Surgery Div, Univ of Tokyo
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Inagaki Yoshinori
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo
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Hasegawa Kiyoshi
HepatcrBiliary-Pancreatic Surgery Div, Univ of Tokyo
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