新規脂質異常症予防治療薬を指向したACAT2選択的阻害剤ピリピロペンAの構造活性相関研究

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Fungal pyripyropene A (PPPA, 1), consisting of pyridine, α-pyrone, and sesquiterpene moieties, is the only potent and selective inhibitor of acyl-CoA: cholesterol acyl transferase 2 (ACAT2) isozyme. In an effort to develop potent and selective inhibitors toward ACAT2, structure-activity relationship studies were carried out using derivatives based on 1. We have successfully developed novel 1,11-O-o-substituted benzylidene-7-p-cyanobenzoyloxy PPPA derivatives that exhibit significantly more potent ACAT2 inhibitory activity and much higher isozyme selectivity than 1.Furthermore, we have achieved a stereocontrolled total synthesis of 1. Key features of the synthetic strategy included an intramolecular Ti(III)-mediated radical cyclization for construction of the A-ring, stereoselective β-epoxide formation/Peterson olefination for preparation of the functional groups on the B-ring, and stereoselective intramolecular cyclization through hetero-Michael addition for C-ring formation. Extension of this chemistry to the synthesis of an A-ring truncated PPPA analog for structure-activity relationship studies has also been achieved.
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