SPECT/CTによるラット嗅神経の画像評価
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概要
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Objective: To image the olfactory nerve in vivo using single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) after nasal thallium-201 (<SUP>201</SUP>Tl) administration to rats.Methods: Three 8-week-old female Wistar rats (Japan SLC, Shizuoka, Japan) used in this study were assessed under anesthesia (intraperitoneal administration of pentobarbital sodium; 0.05 mg/g body weight) for <SUP>201</SUP>Tl transport to the olfactory bulb 8h after nasal administration of <SUP>201</SUP>TlCl solution (50μl, 74 MBq/ml, Nihon Medi-Physics, Tokyo, Japan) using SPECT/CT (Flex X-SPECT, Gamma Medica-Ideas, USA). The heads of rats were assessed for autoradiography to confirm <SUP>201</SUP>Tl transport to the olfactory bulb after SPECT/CT.Results: <SUP>201</SUP>Tl transport to the olfactory bulb was shown using SPECT/CT 8h after nasal administration of <SUP>201</SUP>Tl. Coronal section imaging especially indicated <SUP>201</SUP>Tl transport from the nasal cavity to the olfactory bulb. <SUP>201</SUP>Tl transport to the olfactory bulb was confirmed by autoradiography.Conclusion: SPECT/CT showing <SUP>201</SUP>Tl transport to the olfactory bulb may be useful in visually assessing the olfactory nerve <I>in vivo</I>.
- 日本鼻科学会の論文
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