中頭蓋底進展上顎洞癌に対する非開頭手術による頭蓋底手術成績

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Objectives: The purpose of this study was to examine the oncologic outcome of patients who reveived multimodality therapy for maxillary sinus cancer that had invaded the base of the middle portion of the skull.Study Design: Retrospective study.Patients and Methods: The medical records of 13 patients with maxillary sinus cancer that had invaded the base of the middle portion of the skull were analyzed retrospectively. These were 7 men and 6 women, and their median age was 60 years. The mean follow-up period was 73 months. The pathological diagnosis was squamous cell carcinoma. Two patients had nodal disease. Of the 13 patients, 9 had lesions around the foramen rotundum, 3 had lesions around the foramen ovale, and 3 had lesions around the foramen lacerum. All patients underwent simultaneous multimodality therapy consisting of surgery through a sublabial incision, radiotherapy, and regional chemotherapy. Selective neck dissection was performed in patients with nodal disease.Results: The 5-year overall survival rate was 76%, and the 5-year local control rate was 68%.Conclusion: Multimodality therapy consisting of surgery, radiotherapy, and regional chemotherapy is an effective method of treating maxillary sinus cancer with invasion of the base of the middle portion of the skull.
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