自然光のアザセトロン塩酸塩注射液（セロトーン®静注液）に与える影響に関する研究

概要

論文の詳細を見る
We evaluated the photostability of azasetron hydrochloride injection (Serotone Injection) under several conditions (indoor, outdoor and other conditions). The evaluation revealed that the azasetron hydrochloride content remained 95% or more of the initial content even after storage in an indoor condition (with the window closed, but with exposure to high levels of direct rays). On the other hand, the drug content decreased markedly when the formulation was stored outdoors or in an indoor condition with the window open. When stored outdoors, exposed to direct rays, the drug content decreased to about 47% of the initial amount within only 30 minutes. When stored outdoors in the shade or indoors without exposure to direct rays, the content decreased by only about 25% or less of the initial content. We may therefore conclude that azasetron hydrochloride should be stored and used indoors with the window closed.
日本医療薬学会の論文