非小細胞肺がんに対するペメトレキセド単剤治療における血液毒性の経時的な推移の調査と患者指導への活用
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概要
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We surveyed temporal changes in pemetrexed-induced hematotoxicity in patients with non-small cell lung cancer (NSCLC) in order to determine the appropriate time for measuring blood cell counts during the administration of pemetrexed monotherapy to outpatients. In total, 19 inpatients with NSCLC who were treated with pemetrexed at the Nagara Medical Center from July 2009 to April 2011 were included in our study. The time from administration of pemetrexed until the nadir of white blood cells, thrombocytes, and hemoglobin was reached was 9.5, 10.5, and 12 days, respectively. In an ambulatory setting, the date of physician visit and blood tests to monitor hematotoxicity should be set after considering the time taken to reach the nadir levels of each blood cell and the individuals tendency of hematotoxicity.Next, we investigated the average temporal changes of white blood cells, thrombocytes, and hemoglobin after the administration of pemetrexed in the aforementioned patients, and we plotted graphs of each average temporal change. Then we created a leaflet using these graphs, and after pharmacists explained to outpatients administered pemetrexed about hematotoxicity using the leaflet, we conducted a questionnaire survey of them. As a result, the leaflet was useful for the following items: comprehensibility of the need for blood tests, simplicity of the leaflet using graphs, removal of the concern regarding hematotoxicity, and comprehensibility of the word of caution regarding hematotoxicity in daily life.
- 日本医療薬学会の論文
日本医療薬学会 | 論文
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