脳梗塞治療における新たなるアプローチ:－脳虚血障害発症後の耐糖能異常制御の観点から－
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概要
- 論文の詳細を見る
Stroke is the third most common cause of death in Japan. Although significant breakthroughs have been made in the development of advanced drugs, the necessity for using them in a limited time window and adverse effects can restrict their application, making it still necessary to explore new therapeutic targets and strategies.It is well known that hyperglycemia can exacerbate ischemic neuronal damage. Also, it has been recently reported that hyperglycemia/glucose intolerance can be induced by cerebral ischemic stress per se, and a clinical study showed that normalization of blood glucose levels during the first 48 h of hospitalization appears to confer a potent survival benefit in patients with thromboembolic stroke. It is therefore important to strictly control blood glucose levels immediately after ischemic stress for neruroprotection. However, the detailed mechanism of post-ischemic glucose intolerance is unknown.Here, we review the progress in research on the mechanism of the development of post-ischemic glucose intolerance focusing on insulin signaling, adiponectin signaling and communication between the brain and peripheral tissues. Furthermore, from the therapeutic viewpoint, we discuss the effect of anti-diabetic drugs, such as insulin, metformin, and the glucose-sensing neuropeptide orexin-A, on the development of post-ischemic glucose intolerance and additional neuronal damage. In our conclusion, we emphasize the importance of focusing on the development of post-ischemic glucose intolerance as a new therapeutic target of stroke.
- 日本医療薬学会の論文
日本医療薬学会 | 論文
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