ジゴキシン散の調剤および患者の服用過程における損失に対する湿度の影響
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概要
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The relationship between drug loss and humidity in the dispensing and taking processes of digoxin (DX) powder was examined. We used a commercially available 0.1% DX powder, 0.01% and 0.0333% DX powders prepared by mixing the 0.1% DX powder and the excipient EFC lactose, and powders prepared by adding 1% of either hydrated silicon dioxide or titanium dioxide as a lubricant to the 0.01% and 0.0333% DX powders. For comparison, 0.01% DX granules were also prepared.While the drug loss rates of the DX powders in the taking process were not affected by humidity, loss in the mixing and dividing processes increased significantly when humidity was 50% or lower. At a humidity of 20%, the total drug loss for the commercially available 0.1% DX powder, 0.0333% DX powder, and 0.01% DX powder before taking were 66%, 42%, and 20%, respectively. Total drug loss was decreased by 3-5% through the addition of lubricants to the DX powders. On the other hand, the total drug loss rate for DX granules before taking was 1%, which was lower than that of the powders.The results of this study indicated that the amounts of the principal ingredient of DX powder taken varied widely with humidity for the same prescribed dose. Also the drug loss was not greatly improved by adding an excipient or lubricants to the DX powders. There was little drug loss for the granular form in the course of the dispensing and taking procedures, suggesting that its use would be a useful way of preventing drug loss with DX.
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日本医療薬学会 | 論文
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