ドセタキセルの外来化学療法時における発熱に対する経口抗菌剤のアドヒアランス

概要

論文の詳細を見る
Febrile neutropenia (FN) is a critical condition in outpatient docetaxel chemotherapy. Many studies have provided evidence for the benefit of oral antibiotics in low risk FN patients and in December 2007, the National Cancer Center Hospital East started to use oral antibiotics routinely for the initial management of such patients. However, it is unclear whether oral antibiotics are being taken properly as initial treatment in the outpatient chemotherapy setting. In this study using patient records, we retrospectively investigated adherence in patients who had been prescribed oral antibiotics as needed during outpatient docetaxel chemotherapy between December 2007 and November 2009. Among the 335 subjects in our study, 87 (26%) developed fevers of above 38 degrees Celsius. Of these patients, 74 (85%) started taking oral antibiotics, and 60 patients finished the course of antibiotics as instructed. The frequency of proper use of oral antibiotics was significantly higher in patients who consulted the hospital by telephone than those who did not (88% vs. 51%, p < 0.001).The findings of this study show that most patients started taking oral antibiotics when they developed a fever of above 38 degrees Celsius, but many stopped taking them after the fever was resolved, and that telephone consultation could be beneficial in increasing adherence. However, few patients had to be admitted to the emergency department for treatment.
日本医療薬学会の論文