光触媒を利用した安全キャビネット内残留抗がん剤分解の検討(第2報)

概要

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We have developed a photocatalytic agent (CHEMOCLEAN) containing TiO2 solution and examined its degradation of residual cyclophosphamide (CPA) in a biological safety cabinet (BSC). In this study, the degradation effects of the photocatalyst on various other anticancer drugs were also investigated.A certain concentration of each anticancer drug (CPA, 5-Fluorouracil; 5-FU, Methotrexate; MTX, Paclitaxel; PTX, Iirinotecan; CPT-11) was placed on 100-cm2 stainless plates, and the photocatalytic agent was sprayed at 150 g/m2. Then, the plates were irradiated with near-ultraviolet (wavelength: 350 nm) radiation in the BSC for 12h. The residual drugs were extracted from a paper used to wipe the plates and their concentrations measured using high-performance liquid chromatography. We found that the degradation rate of the anticancer drugs tended to increase with reduction of the loading dose. The photocatalytic solution degraded CPA(50 μg), 5-FU(100 μg), MTX(100 μg), PTX(50 μg), and CPT-11(100 μg)by 78%, 86%, 97%, >99% (below quantification limit), and 87%, respectively.From these results, we conclude that the degradation effect of the photocatalytic agent appears to be similar for every anticancer drug, and that it will be useful for reducing the concentrations of residual anticancer drugs.
日本医療薬学会の論文