イホスファミド連日投与によって引き起こされる悪心,嘔吐,食欲不振に対するデキサメタゾン隔日投与の評価

概要

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It has been reported that antiemetic therapy based on the guidelines produced by the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) is effective in reducing emetic risk.However,they have not been drawn up in assumption of daily administration of antineoplastic drugs.In the present study,we investigated the effectiveness of alternate-day administration of dexamethasone for the prevention of nausea,vomiting and anorexia induced by the daily administration of ifosfamide chemotherapy in 27 eligible patients.During the observation period,the incidence and grade of vomiting were not statistically significant different between the dexamethasone group and a control group in the acute and delayed period.However,the incidences and grades of nausea and anorexia during chemotherapy for the dexamethasone group were lower than those in the control group.These results suggested that the alternate-day administration of dexamethasone could be conducted prophylactically during the daily administration of ifosfamide.
日本医療薬学会の論文