抗菌薬適正使用に向けた注射抗真菌薬使用届出制の評価
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概要
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While it is necessary to use antifungal drugs for opportunistic deep mycosis in patients with immune system dysfunction,the inappropriate use of such drugs needs to be reduced to prevent occurrence of antifungal drug resistance as well as from the pharmacoeconomic viewpoint.In this study,we evaluated a notification system for the proper use of antifungal drugs that was introduced at Ehime University Hospital in January 2008.We investigated changes in antimicrobial use densities (AUD) of antifungal drugs,dosage period,number of patients receiving them and average dosage period of antifungal drugs in β-D glucan negative or unidentified patients from January 2007 to December 2008.After the introduction of the notification system,there was a significant decrease in the average monthly AUD of antifungal drugs (from 12.8±1.8 to 7.6± 1.8 ; p<0.01).The number of patients treated with antifungal drugs for periods of over 12 days and the average dosage period of antifungal drugs in β-D glucan negative or unidentified patients also decreased (p<0.05).These results suggested that the notification system was effective in reducing purposeless empirical therapy and ensuring the proper use of antifungal drugs in our hospital.
- 日本医療薬学会の論文
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