抗がん剤連日投与時の制吐療法の実態調査と評価
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that antiemetic therapy based on the guidelines produced by the National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO) is effective in reducing emetic risk.However,while the effect of antiemetic therapy has been much reported for the intermittent administration of anticancer drugs,there have been few reports on such therapy in the case of the daily administration of anticancer drugs.In the present study,we investigated antiemetic therapy used for the prevention of nausea and vomiting induced by the daily administration of ICE combination chemotherapy (ifosphamide,carboplatin,and etoposide : ICE group) or DeVIC combination chemotherapy (dexamethasone,etoposide,ifosphamide,and carboplatin : DeVIC group) in 30 eligible patients.All patients received 5-HT3 serotonin receptor antagonists prophylactically during the daily administration of both types of chemotherapy but no patient received such prophylactic therapy after the administration of the anticancer drugs.The incidences of nausea and vomiting during chemotherapy for the ICE group (60.0% and 46.7%,respectively) were significantly higher than that in the DeVIC group (6.7% and 0%,respectively) but the incidences were comparable in the ICE (60.0% and 26.7%,respectively) and DeVIC groups (40.0% and 13.3%,respectively) following chemotherapy.These results suggested that dexamethasone could be administered prophylactically during the daily administration of anticancer drugs and its administration should be continued for a few days after the administration of anticancer drugs.
- 日本医療薬学会の論文
日本医療薬学会 | 論文
- O17-003 視覚障害者に対する手技指導の標準化を目的とした視覚障害擬似体験インスリン注射院内実習(一般演題 口頭発表,糖尿病/後発医薬品,医療薬学の創る未来 科学と臨床の融合)
- 20H-16 Basal-Bolus療法におけるインスリンデテミルの有効性(使用状況調査・意識調査,来るべき時代への道を拓く)
- 30-P2-43 2種類のインスリン試薬を用いた化学発光酵素免疫測定法によってFactitious hypoglicemiaを証明しえた一例(副作用・有害事象,社会の期待に応える医療薬学を)
- 28-04-20 ペン型インスリン注射器の精度に及ぼす注入時抵抗とカートリッジ内気泡の影響
- P-610 ファブリー病に対する「ファブラザイム^[○!R]」投与時の「過敏反応発現時の対処方法」の一部改変により副作用防止に至った1症例(8.有害事象・副作用(基礎と臨床)1,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)