パクリタキセル，シスプラチン投与直後のワルファリンカリウムの抗血液凝固作用の増強

概要

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Warfarin potassium (Wf) interacts with a wide range of drugs and occasionally causes severe bleeding.We report the case of a 60-year-old female patient on Wf therapy who received 5 courses of cancer chemotherapy with doxorubicin,paclitaxel,and cisplatin.The Wf dose had to be reduced immediately after the chemotherapy due to an increase in international normalized ratio (INR).We then steadily increased the Wf dose till it had reached the previous level,which took almost 11 days from the time of receiving the anti-cancer agents.Although we could not determine which agent was interacting with Wf to cause the rise in INR in this case,we feel that attention must be paid to Wf drug-interactions for chemotherapy agents that have not previously been reported to interact with Wf in order to avoid the risk of bleeding.Therefore,there is a need for pharmacists to check medicines prescribed to patientsundergoingcancerchemotherapybyothermedicaldepart-ments and other medical clinics,especially for outpatients.
日本医療薬学会の論文