救命救急医療におけるテイコプラニン（ＴＥＩＣ）高用量投与設計法の検討
スポンサーリンク
概要
- 論文の詳細を見る
We analyzed the clinical efficacy and safety of treating MRSA infections with high-dose teicoplanin (TEIC) (800 mg×2 on the first day and 800 mg/day on the following 6 days) and devised a method of predicting serum trough concentrations on the 8th day of administration.Serum trough concentrations were obtained on the 1st day (day 1 ; D1),2nd day (day 2 ; D2),4th day (day 4 ; D4)and 24 hrs after the 7th day of administering TEIC (day 8 ; D8).We also compared the predicted D8 trough concentrations,based on those at D2,D4 and D2 and 4 using a Bayesian method based on the population pharmacokinetic parameters in TEICTDM Ver.2.0,with the actually measured trough concentrations on D8.The results were as follows : 1)The trough concentrations of TEIC on D2,D4 and D8 were 17.1±6.0,18.0±6.3 and 20.8±7.1(mean±SD)μg/mL,respectively ; 2)High-dose treatment with TEIC achieved the effective serum trough concentration (15μg/mL) on day 2,and this treatment method demonstrated clinical and bacteriological efficacy and safety ; 3)Predicted concentrations on D8 calculated from either D2 or D4 levels were 75% and 35% higher than the observed values (p <0.001),respectively,but there was no significant difference when predicted concentrations at D8 were calculated from both D2 and 4.In the present study on treatment with high-dose TEIC,when the Bayesian method was applied,a single sampling point produced low-reliability pharmacokinetic values with large prediction errors,while the use of two sampling points made it possible to predict trough levels with considerable precision.
- 日本医療薬学会の論文
日本医療薬学会 | 論文
- O17-003 視覚障害者に対する手技指導の標準化を目的とした視覚障害擬似体験インスリン注射院内実習(一般演題 口頭発表,糖尿病/後発医薬品,医療薬学の創る未来 科学と臨床の融合)
- 20H-16 Basal-Bolus療法におけるインスリンデテミルの有効性(使用状況調査・意識調査,来るべき時代への道を拓く)
- 30-P2-43 2種類のインスリン試薬を用いた化学発光酵素免疫測定法によってFactitious hypoglicemiaを証明しえた一例(副作用・有害事象,社会の期待に応える医療薬学を)
- 28-04-20 ペン型インスリン注射器の精度に及ぼす注入時抵抗とカートリッジ内気泡の影響
- P-610 ファブリー病に対する「ファブラザイム^[○!R]」投与時の「過敏反応発現時の対処方法」の一部改変により副作用防止に至った1症例(8.有害事象・副作用(基礎と臨床)1,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)