ＦＯＬＦＯＸ療法施行に伴うアレルギー反応に関する多施設共同研究
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概要
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We investigated Oxaliplatin (L-OHP)-related hypersensitivity reactions in 20 Japanese patients with advanced colorectal adenocarcinomas treated with the FOLFOX 4 or mFOLFOX 6 regimen,after separating patients into a non-severe group with reactions of grade 1-2 and a severe group with reactions of grade 3-4.The total number of patients was 90,and the proportion with hypersensitivity reactions was 22.2%,rated as non-severe in 13.3% and severe in 8.9%.We observed the following : 1)hypersensitivity reactions occurred only after the 6th course in the severe group,but this was not true for the non-severe group,and 2)hypersensitivity reactions appeared within 30 min of the start of L-OHP infusion in the severe group,whereas it took more than 30 min for them to be manifested in the non-severe group,with the difference in time being statistically significant (p=0.001 ; Mann-Whitney's U test).These results strongly suggest that the severe hypersensitivity reactions were of type I and thus could be predicted from various skin tests.
- 日本医療薬学会の論文
日本医療薬学会 | 論文
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