抗悪性腫瘍薬調製時の安全キャビネット内無菌性保持の検討
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No studies have been done on maintaining a class II biological safety cabinet in a sterile condition during the preparation of antineoplastic agents. Also, the relationship between maintenance of sterility and preparation time and that between time of irradiation with ultraviolet light (UV) and maintenance of sterility have yet to be studied. With this in mind, we examined the relationship between maintenance of sterility and preparation time in a class II biological safety cabinet and the variation in bacterial extinction with time of exposure to UV lamp irradiation. Regarding the former, we observed that no bacteria colonies were present 15 minutes after the start of antineoplastic agent preparation but from 30 minutes after the start of preparation onwards, a time-dependent increase in the number of colonies was observed. Colony formation did not vary with the part of the safety cabinet the Petri dish was placed in. UV irradiation for 30 seconds markedly suppressed colony formation as compared with the positive control group. We therefore suggest that every antineoplastic preparation be irradiated with for 5 minutes and that this is started 15 minutes after starting to prepare them in a sterile environment.
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