Trasylolの作用と臨床的応用に関する研究

概要

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There have been only a few informations about the effects of Trasylol on the dynamic balance of the coagulation-fibrinolysis system, and the precise mechanism of the effects has not been wholly elucidated. This report presents the data of in vitro, in vivo, and clinical studies on the effects of Trasylol on the coagulation-fibrinolysis system.Results:1. In vitro experiments;Trasylol inhibited the activities of plasmin and plasminogen activator in fibrinolysis, and prolonged PTT in coagulation.2. In vivo experiments;Trasylol possessed inhibitory effects on the fibrinolytic enzyme system (STT shortened, HIT depressed), and on the 1st phase of blood coagulation (PTT prolonged).3. Clinical studies;Trasylol when administered in 12 patients for the purpose of hemostasis, presented significant effects in 3, good effects in 3, and no effect in 6. STT was proved to be very useful for the estimation of activated fibrinolysis.
一般社団法人日本血液学会の論文