免疫抑制療法が奏効した再生不良性貧血における造血回復過程の検討

概要

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Seven patients with aplastic anemia were successfully treated with immunosupressive agents and peripheral blood T cells were cryopreserved before and after the therapy. Inhibitory activity of cryopreserved T cells to autologous CFU-E was examined after hematological remission. Inhibitory activity was detected in 4 patients before commencing the therapy and it disappeared after remission. Hematopoietic recovery of patients with inhibitory T cells occurred soon after initiation of the therapy compared with that of patients without inhibitory T cells. These findings suggest that inhibitory T cells were closely correlated with the pathogenesis and pathophysiology of aplastic anemia.
一般社団法人日本血液学会の論文