小児特発性血小板減少性紫はん病における抗血小板抗体の特異性についての解析
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概要
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Platelet binding immunoglobulins in sera (PBIg) were studied in children with acute and chronic idiopathic thrombocytopenic purpura (ITP), using the microtiter solid-phase enzyme-linked immunosorbent assay (ELISA). Both groups had significantly greater PBIg values than healthy individuals (p<0.001), and 11 of 13 patients with acute ITP (85%), 5 of 6 patients with chronic ITP (83%) showed elevated PBIg values.We analysed binding activities of PBIg to platelet from patients with acute and chronic ITP by the techniques of ultracentrifugation and pepsin digestion. After ultracentrifugation, the values of PBIg from patients with acute ITP were remarkably reduced to the levels found in healthy individuals, whereas those from patients with chronic ITP were higher than those from patients with acute ITP and healthy individuals. After digestion of sera by pepsin, the pepsin-treated sera from patients with chronic ITP still had strong binding activities to platelets, whereas the pepsin-treated sera from patients with acute ITP did not exhibit significant binding activities to platelets.Based on these findings, we can conclude that the majority of PBIg from patients with acute ITP consist of circulating immune complexes, while patients with chronic ITP have antibodies with specificities for platelet-associated antigens.Immunological anlysis of PBIg can help to differentiate acute and chronic ITP of childhood, and can also be of use in the follow-up these diseases.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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