小児悪性リンパしゅ(Non‐Hodgkin's Lymphoma)に対するModified LSA2L2 Protocolの検討
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概要
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Ten children with previously untreated non-Hodgkin's lymphoma (NHL) were treated according to the multi-drug regimen (modified LSA2L2 protocol).Nine of the ten children (90%) obtained complete remission (CR). One child who had central nervous system (CNS) involvement at the time of diagnosis failed to achieve CR. Of the nine children who achieved CR, two had subsequent relapse, one in bone marrow and the other in CNS.The complete remission rate at 24 months was 64.3%, and the two-year survival rate was 71.1%. Three children are off therapy now.Complications were not uncommon, including severe bone marrow suppression, acute renal failure, gastric perforation, intestinal ulceration and esophageal stenosis.Appropriate supportive care was essential for this protocol.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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