進展期非ホジキンリンパしゅ治療における長期生存例の観察 化学療法による治ゆの可能性:—化学療法による治癒の可能性—
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概要
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The results of chemotherapy for non-Hodgkin's lymphoma (NHL) were analysed in 39 patients who had been resistered between January, 1971 and July 1978. Four-drug regimen consisting of bleomycin, vincristine, cyclophosphamide and prednisolone (BVCP or BCOP) was administered in 87% of the patients as an induction therapy. In patients with unfavorable histology (NH, DLPD, DM and DH), median survival of complete responders was significantly longer than that of partial responders and nonresponders (26 months vs 9 months in NH, DLPD and DM, 31 months vs 10 months in DH). Among 23 complete responders, 7 patients (5 DHs and 2 DLPDs) have been in complete remission for 18 to 64 months after cessation of all treatments. This stduy indicated that complete remission was essential for a prolongation of life of patients with NHL, and that advanced NHL was potentially curable by some relevant combination drug regiments.
- 一般社団法人 日本血液学会の論文
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