ＤＩＣの治療　　小児科領域

概要

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The cases with DIC of newborn infants were investigated at the newborn care unit (N.C.U.) of St. Marianna Hospital, Kawasaki city, Japan, from 1978 to 1981. Out of 178 patients suffering from respiratory distress syndrome (RDS) and severe infectious diseases, 26 cases (14.6%) were diagnosed as DIC. Of 137 cases diagnosed as RDS, 16 cases (11.7%) developed into DIC. Out of 41 cases of severe infectious diseases, 10 cases (25%) developed into DIC.Three kinds of therapy, in conjunction with basic therapy for fundamental diseases, were carried out for the treatment of DIC. They were exchange transfusion therapy, therapy with vasoactive agents of which phenoxybenzamine (POB) was mainly used, and heparin therapy.In all cases, the administration of heparin generally resulted in an improvement of the patient's condition. On using exchange transfusion, 4 out of 12 cases with RDS and 2 out of 10 cases with infectious diseases showed inprovement. When exchange transfusion and phenoxybenzamine were employed together, 2 out of 8 cases with RDS showed improvement. Based on the various advantages of each therapy, combined use of three therapies was attempted. The succesful cases with combined use of three therapies were demonstrated.
一般社団法人日本血液学会の論文