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The parenchyma of the human spleen divides into the white pulp as the lymphatic tissue, and the red pulp composed the splenic cord and the venous sinus. The marginal zone consisted of two layers in the human spleen is seen between the white and red pulp. The lymph follicle abuts at the periphery of the periarterial lymphatic sheath in many place. It is thought that the white pulp and the inner layer of the marginal zone composed of medium-sized lymphocytes having a B-cell nature take part in the immunological mechanism in vivo mainly.In the splenic cord of the red pulp as well as the outer layer of the marginal zone, reticular cells and fibers form the reticular meshwork. Macrophages and blood cells are found in these reticular meshwork, in which arterial capillaries terminate open. Namely, direct communication between the arterial capillary and the venous sinus can not be found in the human spleen so far as examined (Open circulation).It seems that the width of the slit between sinus endothelial cells is influenced by the gradient pressure between the splenic cord and the venous sinus, abundant filaments as well as intermediate junction of sinus endothelial cells and the tension of the basement membrane surrounding the sinus wall. Blood cells losing deformability as well as foreign particles which are detained in the reticular meshwork, undergo trapping, phagocytosis, degradation and removal by macrophages. Namely, it is considered that the red pulp and the outer layer of the marginal zone are the filtration bed.It seems that the sheath of the capillary in the human spleen has some filtrating action, although it does not so well develop.The parenchyma of the human spleen is supported by reticular cells. Their cytoplasm had many filaments 40∼60 Å in diameter which were tightly organized as dense bands. It is suggested that these reticular cells may participate in the regulation of blood flow of the human spleen in addition to the cytoskeletal role themselves by these filaments as well as the capsule, trabecula, sheathed capillary and sinus endothelial cell.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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