放射線治療約4年後に硬膜外腫瘤にて再発したホジキン病の1例
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概要
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A 16-year-old girl was admitted to our hospital because of arthralgia in four extremitres since three months. About four years before admission, she had had Hodgkin's disease in a left cervical region and received radiotherapy (2,000 R) with a complete remission. Nine days after the admission, she suddenly complained of low back pain. Seven days later, there appeared motor weakness and hypesthesia below the level of 11th thoracic vertebra, followed by complete paralysis. Myelography demonstrated a epidural tumor at the level of ninth thoracic vertebra. Laminectomy was performed and histopathological findings of the tumor established a relapse of Hodgkin's disease. At this time, she had no lymphadenopathy but slight splenomegaly. She was diagnosed as having stage III involvement. She was given radiotherapy with 3,500 rads to the field where the epidural tumor was present, and chemotherapy with a combination of COPP. The disease relapsed in the left cervical lymph node one month after the completion of six courses of COPP therapy. She was given a combination chemotherapy including Adriamycin, to which she responded well. The neurological symptoms improved remarkably soon after the laminectomy, and disappeard completely after about one year. Thirty months after the laminectomy, she has no findings suggestive of relapse. Treatment for Hodgkin's lymphoma of the spinal epidural space was discussed. The importance of an adequate irradiation dose for radiotherapy of Hodgkin's lymphoma was also stressed.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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