ニトログリコールの血液におよぼす影響に関する研究
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概要
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Although the toxicity of nitroglycerol and nitroglycol, the major ingredients of dynamite, has been well documented regarding their effects on the cardiovascular system, their hemotoxicity has not been fully elucidated. The author observed at the Asa Dynamite Factory that the average blood specific gravity of the employees had been very low and many had been anemic until up to 1962, but their hematologic status was much improved after the renovation of the factory machinery and facilities to reduce the nitroglycol concentrations in the air. Based on these observations, the following experiments were carried out. Nitroglycol in olive oil was injected in the dose of 200 mg/kg to rabbits and NO3, methemoglobin and Heinz bodies were determined. They were increased sharply after the administration and declined thereafter. The life span of erythrocytes was much reduced when studied by the 51Cr tagging method. However, the erythrocyte life span among the nitroglycol handlers was not shown to be shortened by the same method, probably because the test was carried out after the improvement of factory facilities.Tritiated nitroglycol was prepared from 3H-ethylene glycol by nitration. It was diluted out with olive oil and injected to mice and rabbits, and tissue distribution of 3H was determined. 3H was demonstrated in erythrocytes after two hours and 3H concentration in the spleen was markedly increased about the same time, suggesting some damage onto erythrocytes. Urinary excretion of 3H was rapid, but some 3H remained in plasma after 24 hours, in a form not bound to proteins, probably representing breakdown products. In terms of per cent uptake, the liver and kidney were the major organs.
- 一般社団法人 日本血液学会の論文
一般社団法人 日本血液学会 | 論文
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