Pharmacological Mechanism in Slip-Down Behavior of Mice
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概要
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Slip-down from a raised platform was previously found in mice treated with morphine, and this behavior was also recognized in mice treated with a monoamine releaser methamphetamine. Pharmacological examination on the slip-down indicated that the behavior was induced by receptor stimulations by D2 agonist PPHT and 5HT-2 agonist DOI. In mice treated with PPHT, antagonists of D1, α2, 5HT-2 and opioid mu and kappa suppressed the behavior. In mice treated with DOI, antagonists of D1, α2, 5HT-1A, 5HT-3 and opioid mu and delta suppressed the behavior. These present findings suggest that the slip-down was mainly induced by opioid mu receptor activity regulated with monoamine activities. When the slip-down is considered as an anxious behavior, it may be also suggested that the anxiety induced by 5-HT activities furthermore stimulated the behavior via the other opioid receptor activities.
- 東北ジャーナル刊行会の論文
東北ジャーナル刊行会 | 論文
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