Effects of Ketamine and Propofol on the Ratio of Interleukin-6 to Interleukin-10 during Endotoxemia in Rats

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概要

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• Our previous study reported that the change in the ratio of interleukin (IL)-6 to IL-10 influences the severity of sepsis in patients with systemic inflammatory response syndrome. We evaluated the change in the ratio of IL-6 to IL-10 after administration of ketamine or propofol in endotoxin-exposed rats in order to evaluate the relationship of pro-inflammatory and anti-inflammatory cytokines following ketamine or propofol administration during endotoxemia. We randomly assigned 40 rats to one of four equal groups: endotoxin alone, receiving Escherichia coli endotoxin (15 mg-/kg, i.v.); saline control; ketamine (10 mg·kg−1·h−1, i.v.) before and during exposure to endotoxin; and propofol (10 mg·kg−1·h−1, i.v.) before and during exposure to endotoxin. We measured the plasma concentrations of tumor necrosis factor (TNF)-α, IL-6, and IL-10 and calculated the ratio of IL-6 to IL-10 in each group. The current study showed that ketamine and propofol administration attenuated the increase in TNF-α, IL-6, and IL-10, and ketamine attenuated the increase in the ratio of IL-6 to IL-10, but propofol increased this ratio in rats receiving a single intravenous bolus of endotoxin. While the mechanisms responsible for the inhibitory effects require further investigation, our results suggest that proper use of ketamine as an anesthetic agent may offer certain advantages in the management of patients with endotoxemia.

• 東北ジャーナル刊行会の論文
• 2003-06-01

著者

• Takemoto Yasuhiro

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• TANIGUCHI TAKUMI

  Department of Emergency and Critical Care Medicine Graduate School of Medical Science, Kanazawa Univ

• KANAKURA HIROKO

  Department of Anesthesiology and Intensive Care Medicine Graduate School of Medical Science, Kanazaw

• YAMAMOTO KEN

  Department of Anesthesiology and Intensive Care Medicine Graduate School of Medical Science, Kanazaw

• Kidani Yoko

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• Kanakura Hiroko

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• Taniguchi Takumi

  Department Of Communications Engineering Osaka University

• Taniguchi Takumi

  金沢大学 大学院医学系研究科血液情報発信学(救急医学)

• Kanakura Hiroko

  金沢大学 医学系研究科麻酔蘇生学

• Takemoto Yasuhiro

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• Yamamoto Ken

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• Yamamoto Ken

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

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