Specificity of 4'''-Acetylation by an Aminoglycoside-Modifying Enzyme in Arbekacin-Resistant Strains of Methicillin-Resistant Staphylococcus aureus.
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Four arbekacin (ABK)-resistant clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) were studied regarding their mechanism of aminoglycoside-resistance. Metabolites of amikacin (AMK) and gentamicin(GM) were obtained by reaction with excess amounts of crude enzyme preparation extracted from the ABK-resistant MRSA strains. Then the metabolites were then isolated and analyzed by means of 1H, 13C-nuclear magnetic resonance. The AMK-modification was 4'''-N-acetylation. However, the site of GM-acetylation may be 6'-N-position by these strains.
- 東北ジャーナル刊行会の論文
東北ジャーナル刊行会 | 論文
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