長期経口投与によるカドミウムのマウス肝・腎への蓄積―大気マイクロＰＩＸＥによる組織内カドミウムの測定―:—大気マイクロPIXEによる組織内カドミウムの測定—
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概要
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ICR female mice were allowed free access to water to which Cd (CdCl<SUB>2</SUB>) was added at levels of 100mg/l. Mice were sacrificed and liver and kidney were removed immediately after 18 and 24 months. Three <I>μ</I>m paraffin sections of the organs were prepared for HE stain and immunohistochemical stain for metallothionein (MT). Ten <I>μ</I>m frozen sections of the organs were prepared for detection of Cd using In-air micro-PIXE system. Histological changes and MT expression were observed in the liver cells and the renal proximal tubular epithelium after Cd administration for 18 and 24 months. Using in-air micro-PIXE, Cd accumulation in the liver and kidney were detected in the mouse administratied Ca for 24 months but not detected in the mouse administratied Ca for 18 months.
- 日本微量元素学会の論文
日本微量元素学会 | 論文
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