高脂肪食投与ラットを用いた亜鉛（ＩＩ）錯体の抗肥満作用に関する研究

概要

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The objective of this study is to investigate the effects of zinc(II)molecular complex with ascorbic acid (Zn(VC)2), carnitine (Zn(Car)2Cl2), and glutamine (Zn(Gln)2) on obesity and blood fluidity. We fed the high fat diet which consisted of 40% fat in the energy ratio to the male Wistar rats from 8 weeks of age for 10 weeks of period with or without Zn (II) complexes. Zinc(II) complexes were mixed to the diet as 30∼50 mg Zn/kg body weight. The body weight and body fat composition have been intactly measured once a week. The remarkable body weight reduction was observed by Zn(VC)2 and Zn(Car)2Cl2 mixed diet groups compared to the control groups. The accumulation of abdominal adipose tissues was diminished in Zn(VC)2 and Zn(Car)2Cl2 groups compared to the control groups. We observed the tendency of improved blood fluidity at the 18th week of age measured by micro channel array analyzer (Bloody 6-7) in three Zn (II) complexes groups compared to control groups. These results suggested that zinc (II) complexes with vitamin C, carnitine, and glutamine have suggest the preventive effects of life-style related diseases such as obesity and diabetes.
日本微量元素学会の論文